Potassium Carbonate → HCID 57819888, compound

Participants

Reaction Conditions

Reaction Steps

To N-[(3-bromophenyl)methyl]-N′-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}propanediamide (1.356 g, 2.432 mmol) was added (3-formylphenyl)boronic acid (0.401 g, 2.68 mmol) followed by K2CO3 (1.008 g, 7.30 mmol) and PdCl2(dppf) (0.071 g, 0.097 mmol) in 1,4-dioxane (14.95 mL) and water (4.98 mL). The mixture was heated under microwave for 15 min at 130° C. The solvent was removed by Glas-Col and DCM was added. The crude product was filtered through sintered glass funnel. Then the solid was washed with water and DCM to afford 1.0023 g (70.7%) of the title compound. LC-MS (M+H)+ 583.

Provenance & Evidence