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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 657439Generated: October 25, 2026

Orotic Acid → Creatine orotate

https://huagongshe.com/reaction/657439

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOrotic AcidHCID 967—
ReactantCreatine MonohydrateHCID 80116—
SolventEthanolHCID 702—
ProductCreatine orotateHCID 12135009—

Reaction Steps

Under room temperature 149 grams of creatine monohydrate is slowly added to 1.5 liters of ethanol under agitation and stirring for 30 minutes. Then 156 grams of orotic acid is slowly added to the mixture during continuous stirring for 4 hours under room temperature. Finally filtration is utilized to remove the solvent and clean the residue with ethanol. After drying 272 grams of creatine orotate is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUSRE043029E1
Source datasetuspto-grants-2011_12
ORD IDord-90a9bcc616464073b559974dbcdb47a5
Source noteuspto-grants-2011_12