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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 65747Generated: October 28, 2026

Methyl isothiocyanate → ether N-[5-(5-(dimethylamino)methyl-2-furanyl]pentyl]-N'-methylthiourea

https://huagongshe.com/reaction/65747

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl isothiocyanateHCID 11167—
Reactant5-[5-(Dimethylamino)methyl-2-furanyl]pentanamineHCID 20213289—
SolventAcetonitrileHCID 6342—
Productether N-[5-(5-(dimethylamino)methyl-2-furanyl]pentyl]-N'-methylthioureaHCID 23452166—

Reaction Steps

5-[5-(Dimethylamino)methyl-2-furanyl]pentanamine (0.5 g) and methylisothiocyanate (0.25 g) were stirred in acetonitrile at room temperature for 24 hr. Solvent was removed and the product purified by column chromatography (silica/methanol) to give after trituration with ether N-[5-(5-(dimethylamino)methyl-2-furanyl]pentyl]-N'-methylthiourea as off-white crystals m.p. 66°-69°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04128658
Source datasetuspto-grants-1978_12
ORD IDord-22ef1b9a3b5e41a6b44a780f86eab5f4
Source noteuspto-grants-1978_12