Ammonia → HCID 86761454, compound

HRID 657473Notes

Reaction equation

HRID 657473 reaction equation
[N:1]1([C:9]2([O:35][CH2:34][C@H:21]([O:22][CH2:23][P:24]([O:30][CH:31]([CH3:33])[CH3:32])([O:26][CH:27]([CH3:29])[CH3:28])=[O:25])[C@H:11]2[O:12]C(=O)C2C=CC=CC=2)[OH:10])[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].N>CO>[N:1]1([C:9]2([O:35][CH2:34][C@H:21]([O:22][CH2:23][P:24]([O:26][CH:27]([CH3:29])[CH3:28])([O:30][CH:31]([CH3:32])[CH3:33])=[O:25])[C@H:11]2[OH:12])[OH:10])[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86761455HCID 86761455, compound

Product 1

HCID 86761454HCID 86761454, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 13 (2.03 g, 4.0 mmol) in MeOH saturated with ammonia (300 mL) was stirred at room temperature overnight. The mixture was concentrated, and the residue was purified by column chromatography (CH2Cl2:MeOH=20:1) to give compound 17 (1.52 g, 3.8 mmol) as a white powder in 96% yield which was characterized as follows:

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by column chromatography (CH2Cl2:MeOH=20:1)

Sources & evidence

ORD record
ord-85af15eddea94dffa459b8079f66c2c1
Source dataset
uspto-grants-2011_12
Patent number
US08076310B2

Reaction notes

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