Ammonia → HCID 86761456, compound

HRID 657474Notes

Reaction equation

HRID 657474 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][N:8]([C:11]2([O:37][CH2:36][C@H:23]([O:24][CH2:25][P:26]([O:32][CH:33]([CH3:35])[CH3:34])([O:28][CH:29]([CH3:31])[CH3:30])=[O:27])[C@H:13]2[O:14]C(=O)C2C=CC=CC=2)[OH:12])[C:7](=[O:38])[N:6]=1)(=O)C.N>CO>[N:8]1([C:11]2([O:37][CH2:36][C@H:23]([O:24][CH2:25][P:26]([O:28][CH:29]([CH3:31])[CH3:30])([O:32][CH:33]([CH3:34])[CH3:35])=[O:27])[C@H:13]2[OH:14])[OH:12])[CH:9]=[CH:10][C:5]([NH2:4])=[N:6][C:7]1=[O:38]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86761457HCID 86761457, compound

Product 1

HCID 86761456HCID 86761456, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 14 (450 mg, 0.84 mmol) in MeOH saturated with ammonia (100 mL) was stirred at room temperature overnight. The mixture was concentrated, and the residue was purified by column chromatography (CH2Cl2:MeOH=20:1) to give compound 18 (281 mg, 0.72 mmol) as a white powder in 86% yield which was characterized as follows:

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by column chromatography (CH2Cl2:MeOH=20:1)

Sources & evidence

ORD record
ord-036e24b7904f479490c1268cb7e02e6a
Source dataset
uspto-grants-2011_12
Patent number
US08076310B2

Reaction notes

Loading…