HCID 86761454, compound → HCID 86761466, compound

HRID 657477Notes

Reaction equation

HRID 657477 reaction equation
[Na:1].N1C(N)=C2C(N(C3(OC[C@H](OCP(O)(O)=O)[C@H]3O)O)C=N2)=NC=1.[N:25]1([C:33]2([O:51][CH2:50][C@H:37]([O:38][CH2:39][P:40]([O:46]C(C)C)([O:42]C(C)C)=[O:41])[C@H:35]2[OH:36])[OH:34])[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]1=[O:27]>>[Na:1].[N:25]1([C:33]2([O:51][CH2:50][C@H:37]([O:38][CH2:39][P:40]([OH:42])([OH:46])=[O:41])[C@H:35]2[OH:36])[OH:34])[CH:32]=[CH:31][C:29](=[O:30])[NH:28][C:26]1=[O:27]

Participants

3

Reactant 2

HCID 86761454HCID 86761454, compoundHCID 86761463HCID 86761463, compound

Product 1

HCID 86761466HCID 86761466, compoundYield 49%

Procedure

This compound was prepared as described for 3a using 17 (200 mg, 0.53 mmol) as a starting material and TBMSBr (200 mL, 2.1 mmol). Compound 3c (93 mg, 0.26 mmol) was obtained as a colorless solid, in 49% yield, which was characterized as follows:

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-022a9f3f1587435c97a931f380266b43
Source dataset
uspto-grants-2011_12
Patent number
US08076310B2

Reaction notes

Loading…