Sodium Hydroxide → HCID 59442608, compound

HRID 657510Notes

Reaction equation

HRID 657510 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[CH2:11][CH2:10][C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]2)[CH2:3][CH2:2]1.[OH-].[Na+:29]>O>[CH:1]1([CH2:4][O:5][C:6]2([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[CH2:7][CH2:8][C:9]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)([C:12]([O-:14])=[O:13])[CH2:10][CH2:11]2)[CH2:3][CH2:2]1.[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59442609HCID 59442609, compound

Product 1

HCID 59442608HCID 59442608, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

185 mg of 4-cyclopropylmethoxy-4-(4-fluorophenyl)-1-phenylcyclohexanecarboxylic acid were treated with 0.5 ml of a 1 M sodium hydroxide solution and 2 ml of water and cautiously heated to 100° C. The solution became clear. The sodium salt crystallized during cooling. It was filtered off with suction and dried. 155 mg of the title compound were obtained as silvery white flakes.

Workup

  1. customThe sodium salt crystallized
  2. temperatureduring cooling
  3. filtrationIt was filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-37d5c57012414db0b7662ac5b4f86fae
Source dataset
uspto-grants-2011_12
Patent number
US08076324B2

Reaction notes

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