Sodium Carbonate → HCID 23452138, compound

HRID 65752Notes

Reaction equation

HRID 65752 reaction equation
Cl.Cl.[CH3:3][N:4]([CH2:6][C:7]1[O:11][C:10]([CH2:12][S:13][CH2:14][CH2:15][NH2:16])=[CH:9][CH:8]=1)[CH3:5].[O-:17][C:18]#[N:19].[K+].C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:5][N:4]([CH2:6][C:7]1[O:11][C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:18]([NH2:19])=[O:17])=[CH:9][CH:8]=1)[CH3:3]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 11378442Potassium cyanateHCID 189238085-{[(2-Aminoethyl)-thio]-methyl}-N,N-dimethyl-2-furanmethanamine dihydrochl

Product 1

HCID 23452138HCID 23452138, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine dihydrochloride (2.8 g) and potassium cyanate (3.75 g) in water (50 ml) was heated on a steam bath for 8 hr. Excess solid sodium carbonate was added and organic material continually extracted with diethyl ether. The extracts were evaporated and the residue after column chromatography yielded N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]urea as a waxy solid (1.28 g). Analysis Found: C, 48.22; H, 7.50; N, 15.61. C11H19N3O2S.H2O requires: C, 48.00; H, 7.63; N, 15.27%.

Workup

  1. extractionorganic material continually extracted with diethyl ether
  2. customThe extracts were evaporated

Sources & evidence

ORD record
ord-f2db6690448f462bbadc3bd4f14a83c5
Source dataset
uspto-grants-1978_12
Patent number
US04128658

Reaction notes

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