Water → HCID 131729319, compound

Participants

Reaction Steps

7.9 g (44.6 mmoles) of (5,6-dihydrocyclobuta[4,5]benzo[1,2-d][1,3]dioxol-5-ylmethyl)amine are dissolved in 80 mL of dichloromethane. 80 mL of water and 6 mL (1.6 equivalents) of (12N) aqueous sodium hydroxide solution are added. Over 15 minutes there are added 3.95 mL (1.1 equivalents) of ethyl chloroformate and stirring is carried out at 25° C. for 2 hours. The mixture is separated and the organic phases is washed with saturated aqueous NaHCO3 solution. Drying over MgSO4, filtration and evaporation to dryness are carried out. The expected product is obtained in the form of a brown solid.

Provenance & Evidence