HCID 19092194, compound → HCID 68973917, compound

Participants

Reaction Steps

5 g (2.3 mmoles) of (5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)acetonitrile are dissolved in 50 ml of methanol. 50 mL of a (7N) MeOH—NH3 solution and 0.5 g of Raney nickel are then added. Hydrogen is carried out for 4 days under a pressure of 5 bar, at 25° C. Filtration over Celite and evaporation of the filtrate to dryness are carried out. The residue is taken up in 50 mL of HCl (1N) and washed with ethyl acetate; the aqueous phase is then brought to pH=10 by adding NaOH (20%). Extraction with Et2O, washing with water, drying over MgSO4, filtration and evaporation to dryness are carried out. The expected product is obtained in the form an oil.

Provenance & Evidence