[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]methylamine → N-[(5,6-Dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1-amine hydrochloride

HRID 657559Notes

Reaction equation

HRID 657559 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH:8]([CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][C:18](N1CCC3C=C(OC)C(OC)=CC=3CC1)=[O:19])[CH2:7]2.[CH3:36][O:37][C:38]1[CH:39]=[C:40]2[C:43](=[CH:44][C:45]=1[O:46][CH3:47])[CH:42]([CH2:48][NH:49][CH3:50])[CH2:41]2.[CH3:51]OC1C=C2C(=CC=1OC)CC(CNC)C2>>[ClH:1].[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:6](=[CH:5][C:4]=1[O:3][CH3:2])[CH2:7][CH:8]([CH2:14][N:15]([CH3:35])[CH2:16][CH2:17][C:18]([N:49]1[CH2:50][CH2:41][C:40]3[CH:39]=[C:38]([O:37][CH3:36])[C:45]([O:46][CH3:47])=[CH:44][C:43]=3[CH2:42][CH2:48]1)=[O:19])[CH2:51]2

Participants

4

Reactant 3

HCID 19092217[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]methylamineHCID 222623581-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamineHCID 68972400N-[(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1amine hydrochloride

Product 1

HCID 68971772N-[(5,6-Dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1-amine hydrochloride

Procedure

Obtained in the same manner as the product of Example 1, but with replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by [(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]methylamine.

Sources & evidence

ORD record
ord-1477f36849714f12ac1a86cf08da8a5b
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

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