Fumaric Acid → N-[(2,3,4-Trimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-3-oxopropan-1-amine hemifumarate
Reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH:8]([CH2:14][N:15](C)[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:7]2.[CH3:36][O:37][C:38]1[CH:39]=[C:40]2[C:43](=[CH:44][C:45]=1[O:46][CH3:47])[CH:42]([CH2:48][NH:49][CH3:50])[CH2:41]2.[C:51]([OH:58])(=[O:57])/[CH:52]=[CH:53]/[C:54]([OH:56])=[O:55]>>[C:51]([OH:58])(=[O:57])/[CH:52]=[CH:53]/[C:54]([OH:56])=[O:55].[CH3:54][O:55][C:39]1[C:38]([O:37][CH3:36])=[C:45]([O:46][CH3:47])[CH:44]=[C:43]2[C:40]=1[CH2:41][CH:42]2[CH2:48][NH:49][CH2:50][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:23]=2[CH2:22][CH2:21]1)=[O:19].[CH3:36][O:37][C:5]1[C:4]([O:3][CH3:2])=[C:11]([O:12][CH3:13])[CH:10]=[C:9]2[C:6]=1[CH2:7][CH:8]2[CH2:14][NH:15][CH2:16][CH2:17][C:18](=[O:19])[N:20]1[CH2:21][CH2:22][C:23]2[CH:30]=[C:29]([O:31][CH3:32])[C:28]([O:33][CH3:34])=[CH:27][C:24]=2[CH2:25][CH2:26]1Participants
4
Reactant 3
Product 1
Procedure
Obtained in the same manner as the product of Example 1, but with replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by the product of Preparation 11. Conversion to a salt is carried out in the presence of fumaric acid.
Sources & evidence
- ORD record
- ord-762f897812ab48e69298d20cd4e86d95
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076325B2
Reaction notes
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