Dimethylcarbamoyl Chloride → HCID 68971603, compound

Participants

Reaction Steps

At ambient temperature, to 0.7 g (1.65 mmol) of the compound of Example 43 in 5 ml of pyridine, there are added, all at once, 0.3 mL (2.06 mmol/1.25 eq.) of triethylamine and then, dropwise, 0.2 mL (2.06 mmol/1.25 eq.) of dimethylcarbamoyl chloride. Stirring is carried out at ambient temperature overnight and the mixture is then concentrated. The residue is chromatographed over 130 g of silica (eluant: dichloromethane/ethanol/ammonia: 95/5/0.5) to yield the expected product in the form of the base. It is dissolved in 7 mL of ethanol and treated with 0.5 mL of 3N ethanolic HCl to yield the hydrochloride.

Provenance & Evidence