Isopropyl iodide → HCID 68973796, compound

Participants

Reaction Steps

1.4 g (2.7 mmoles) of the product of Step 1 are dissolved in 15 mL of DMF. There are then added 740 mg (2 equivalents) of potassium carbonate, 160 mg (0.18 equivalent) of caesium carbonate and 0.54 mL (2 equivalents) of isopropyl iodide. Heating is then carried out at 40° C. for 24 hours. The DMF is evaporated off using a rotary evaporator. The residue obtained is then diluted with water and extracted with CH2Cl2. The organic phase is then dried over MgSO4, filtered and evaporated to dryness. An oil is obtained which is purified by flash chromatography over 100 g of silica (eluant: CH2Cl2/ethyl acetate: 80/20) to yield the expected product in the form of a sticky meringue.

Provenance & Evidence