Thionyl Chloride → HCID 57624577, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-[3,5-dichloro-4-(1-hydroxymethyl-5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonitrile (600 mg, 1.29 mmol) in tetrahydrofuran (9.0 mL, 0.14 M) cooled to 0° C. was treated with thionyl chloride (0.28 mL, 3.84 mmol). The reaction mixture was allowed to slowly warm to 25° C. The reaction mixture was stirred at 25° C. overnight. At this time, the reaction mixture was concentrated in vacuo. The residue was taken up in benzene and was re-concentrated twice to afford 2-[3,5-dichloro-4-(1-chloromethyl-5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonitrile as a yellow solid. The material was used without further purification.

Provenance & Evidence