Methane → HCID 178511500, compound

Participants

Reaction Steps

A suspension of trans-N-benzyl-4-(4-hydroxyphenyl)cyclohexanamine (7.69 g) and palladium over charcoal (800 mg) in methanol (300 mL) is stirred at a temperature close to 40° C. for 8 h under a pressure of 15 bar of dihydrogene. Filtration over celite and evaporation of the solvent under reduced pressure affords 4.9 g of trans-4-(4-hydroxyphenyl)cyclohexanamine as a white powder. trans-N-benzyl-4-(4-hydroxyphenyl)cyclohexanamine can be prepared as described in WO 01/81295 (Warner-Lambert Company).

Provenance & Evidence