5-Aminovaleric acid → HCID 23150292, compound

HRID 657624Notes

Reaction equation

HRID 657624 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17](O)=O>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][N:12]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 1385-Aminovaleric acidHCID 76917(3-Chloropropoxy)benzene

Product 1

HCID 23150292HCID 23150292, compoundYield 30.4%

Procedure

Following the procedure described in example 15§A, but starting from O-(3-chloropropyl)phenol (3.55 g), 5-aminopentanoic acid (2.39 g) and polyphosphoric acid (36 g) gives 1.563 g of 6-[4-(3-chloropropoxy)phenyl]-2,3,4,5-tetrahydropyridine.

Sources & evidence

ORD record
ord-0a1b54fd880c4a30b9923f734ac3dfc9
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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