Potassium Carbonate → HCID 15941902, compound

Participants

Reaction Steps

A suspension of potassium carbonate (760 mg) in a solution of 1-{3-[4-(4-tosyloxybut-1-yn-1-yl)phenoxy]propyl}piperidine (487 mg) in a mixture of piperidine (1.09 mL) and acetonitrile (8 mL) is heated at a temperature close to 60° C. for 24 h. The suspension is filtrated. The filtrate concentrated under reduced pressure and purified by chromatography over silica gel using a gradient dichloromethane/methanol from 100/0 to 95/5. Fraction containing the expected product are pooled, concentrated under reduced pressure and salted with oxalic acid to give 190 mg of 1-{3-[4-(4-piperidinobut-1-yn-1-yl)phenoxy]propyl}piperidine as an off white solid melting at 167° C.

Provenance & Evidence