HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 23150257, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Oxalate | HCID 71081 | — |
| Reactant | 1-(Prop-2-yn-1-yl)piperidine | HCID 336652 | — |
| Reactant | 1-{3-[(4'-Bromobiphenyl-4-yl)oxy]propyl}piperidine | HCID 23150313 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 23150257 | HCID 23150257 | 21.4% |
Reaction Steps
Following the procedure described in example 43§C, but starting from 1-{3-[(4′-bromobiphenyl-4-yl)oxy]propyl}piperidine (0.75 g), 1-prop-2-yn-1-ylpiperidine (320 mg), triethylamine (20 mL), cuprous iodide (4.2 mg), triphenylphosphine (20 mg) and bis(triphenylphosphinepalladiumdichloride) affords 179 mg of 1-(3-{[4′-(3-piperidinoprop-1-yn-1-yl)biphenyl-4-yl]oxy}propyl)piperidine which oxalate melts at 195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076329B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-8ac4ff95480b4bbaaaf4254bd7871ada |
| Source note | uspto-grants-2011_12 |