Potassium Carbonate → HCID 15940788, compound

Participants

Reaction Steps

A A mixture of 4-(4-hydroxyphenyl)pyridine 1-oxide (250 mg), potassium carbonate (560 mg) and 1-(3-chloropropyl)piperidine, hydrochloride in N,N-dimethylformamide (10 mL) is heated at a temperature close to 65° C. overnight, then cooled back to room temperature and filtered. The filtrate is concentrated under reduced pressure and the residue purified by chromatography over silica gel (eluent dichloromethane/methanol from 100/0 to 90/10). Fraction containing the compound are pooled and concentrated under reduced pressure. Crude base is diluted with ethanol, oxalic acid (28 mg) is added and solvent removed under reduced pressure to give 40 mg of 4-[4-(3-piperidino-propoxy)phenyl]pyridine 1-oxide, oxalate as a viscous yellow product.

Provenance & Evidence