Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-cyano-N'-[2-[[[2-furanyl]methyl]thio]ethyl]-N"-methylguanidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Cyano-2,3-dimethylisothiourea | HCID 111103 | — |
| 반응물 | 2-(Furfurylthio)ethylamine | HCID 118970 | — |
| 촉매 | Silver Nitrate | HCID 24470 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-cyano-N'-[2-[[[2-furanyl]methyl]thio]ethyl]-N"-methylguanidine | HCID 53954457 | 34.7% |
반응 단계
A solution of silver nitrate (8.25 g) in dimethylformamide (50 ml) was added dropwise to a solution of N-cyano-N'-methylcarbamimidothioic acid, methyl ester (6.1 g), triethylamine (4.8 g) and 2-[[[2-furanyl]methyl]thio]ethanamine (7.8 g) in methanol (150 ml). After 42 hr at 50° the mixture was filtered and the filtrate evaporated. The residue was partitioned between ethyl acetate and water. The organic layers were dried and evaporated to give an oil which yielded crystalline N-cyano-N'-[2-[[[2-furanyl]methyl]thio]ethyl]-N"-methylguanidine (3.9 g) m.p. 78°-82°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04128658 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-317570242a8c4a838cacab684ca4bc30 |
| 출처 메모 | uspto-grants-1978_12 |