HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-methyl-4-(4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3S)-1-(3-methane-sulfonyloxypropyl)-3-methylpiperidine hydrochloride | HCID 86629975 | — |
| Reactant | 2-Methyl-4-(4-hydroxyphenyl)pyridine hydrobromide | HCID 136336053 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-methyl-4-(4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)pyridine | HCID 15940926 | — |
Reaction Steps
A Following the procedure described in example 56A, but starting from 2-methyl-4-(4-hydroxyphenyl)pyridine hydrobromide (130 m g), potassium carbonate (415 g), (3S)-1-(3-methanesulfonyloxypropyl)-3-methylpiperidine hydrochloride (170 mg) and N,N-dimethylformamide (5 mL) gives 82 mg of 2-methyl-4-(4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)pyridine, dioxalate as a pale yellow powder melting at 97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076329B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-e0088885c2264b5d9e5fcb27b8643c4c |
| Source note | uspto-grants-2011_12 |