反应详情

To a solution of 1-[3-(4-hydroxymethylphenoxy)propyl]piperidine (5.617 g) in dichloromethane (50 mL), cooled at a temperature close to 0° C., is added dropwise thionyl chloride (3 mL). The mixture is stirred for 18 hours at room temperature and concentrated under reduced pressure. The residue is crystallized in diethyl ether to give 1-[3-(4-chloromethylphenoxy)propyl]piperidine as an off white solid used without further purification.

1. customclose to 0° C.
2. concentrationconcentrated under reduced pressure
3. customThe residue is crystallized in diethyl ether