Hydrogen chloride-ethyl acetate → HCID 67424541, compound

HRID 657709Notes

Reaction equation

HRID 657709 reaction equation
[ClH:1].C(OCC)(=O)C.[NH2:8][C:9](=[N:11][C:12]([C:14]1[CH:26]=[CH:25][C:24]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]([CH:27]3[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]3)[C:16]=2[CH:15]=1)=[O:13])[NH2:10]>C(O)C>[ClH:1].[ClH:1].[NH2:10][C:9]([NH2:8])=[N:11][C:12]([C:14]1[CH:26]=[CH:25][C:24]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]([CH:27]3[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]3)[C:16]=2[CH:15]=1)=[O:13]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67425532HCID 67425532, compound

Product 1

HCID 67424541HCID 67424541, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 0.6 ml portion of 4 M hydrogen chloride/ethyl acetate was added to 4.4 ml ethanol solution of 201 mg tert-butyl 4-(2-{[(diaminomethylene)amino]carbonyl}-9H-carbazol-9-yl)piperidine-1-carboxylate which had been synthesized in the same manner as in Example 1, followed by stirring overnight at room temperature. The thus precipitated-solid was collected by filtration and washed with EtOH to obtain 125 mg of N-(diaminomethylene)-9-piperidin-4-yl-9H-carbazole-2-carboxamide dihydrochloride as pale yellow solid.

Workup

  1. customhad been synthesized in the same manner as in Example 1
  2. filtrationThe thus precipitated-solid was collected by filtration
  3. washwashed with EtOH

Sources & evidence

ORD record
ord-1baf63c236a04b729a2b308d9432ee8c
Source dataset
uspto-grants-2011_12
Patent number
US08076348B2

Reaction notes

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