Sodium borohydride → HCID 59395108, compound

HRID 657710Notes

Reaction equation

HRID 657710 reaction equation
[BH4-].[Na+].[NH2:3][C:4]([NH2:21])=[N:5][C:6]([C:8]1[CH:19]=[CH:18][C:17]2[C:16]3[CH:15]=[CH:14][S:13][C:12]=3[C:11](=[O:20])[C:10]=2[CH:9]=1)=[O:7]>CO>[NH2:21][C:4]([NH2:3])=[N:5][C:6]([C:8]1[CH:19]=[CH:18][C:17]2[C:16]3[CH:15]=[CH:14][S:13][C:12]=3[CH:11]([OH:20])[C:10]=2[CH:9]=1)=[O:7]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 59395098HCID 59395098, compound

Product 1

HCID 59395108HCID 59395108, compoundYield 100.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 156 mg portion of sodium borohydride was added to a 10 ml methanol suspension of 280 mg N-(diaminomethylene)-8-oxo-8H-indeno[2,1-b]thiophene-6-carboxamide, followed by stirring at room temperature for 30 minutes. After evaporation of the solvent, the solid precipitated by adding water was purified by Chromatorex (DMF/chloroform) to obtain 284 mg of N-(diaminomethylene)-8-hydroxy-8H-indeno[2,1-b]thiophene-6-carboxamide as a pale green solid.

Workup

  1. customAfter evaporation of the solvent
  2. customthe solid precipitated
  3. additionby adding water
  4. customwas purified by Chromatorex (DMF/chloroform)

Sources & evidence

ORD record
ord-e181345536bb4a6b8efffa7833ffd9aa
Source dataset
uspto-grants-2011_12
Patent number
US08076348B2

Reaction notes

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