6-Benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine → N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 657773노트

반응식

HRID 657773 반응식
C([N:8]1[CH2:29][CH2:28][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:16][CH2:17][C:18]3[CH:19]=[N:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=3)[C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:26][C:24]([F:25])([F:27])[C:21]1[N:20]=[CH:19][C:18]([CH2:17][NH:16][C:15]2[C:10]3[CH2:9][NH:8][CH2:29][CH2:28][C:11]=3[N:12]=[CH:13][N:14]=2)=[CH:23][CH:22]=1

참가 물질

4

반응물 1

HCID 598407136-Benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

생성물 1

HCID 59840682N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine수율 83.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 6-benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (7.41 g, 18.6 mmol), methanol (300 mL), and 10% palladium on charcoal (1.0 g) was evacuated and purged with hydrogen 3 times, then hydrogenated (1 atm) at room temperature for 2 days. The mixture was filtered through a pad of Celite and the filter cake was washed with MeOH. The filtrate was concentrated in vacuo to yield a pale yellow foam (4.8 g). LC-MS: 310.4 [M+H]+

후처리

  1. customwas evacuated
  2. custompurged with hydrogen 3 times
  3. filtrationThe mixture was filtered through a pad of Celite
  4. washthe filter cake was washed with MeOH
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-d6179fcafc0440ad85d8521f98acba1a
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076345B2

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