反应详情

A mixture of 6-benzyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (7.41 g, 18.6 mmol), methanol (300 mL), and 10% palladium on charcoal (1.0 g) was evacuated and purged with hydrogen 3 times, then hydrogenated (1 atm) at room temperature for 2 days. The mixture was filtered through a pad of Celite and the filter cake was washed with MeOH. The filtrate was concentrated in vacuo to yield a pale yellow foam (4.8 g). LC-MS: 310.4 [M+H]+

1. customwas evacuated
2. custompurged with hydrogen 3 times
3. filtrationThe mixture was filtered through a pad of Celite
4. washthe filter cake was washed with MeOH
5. concentrationThe filtrate was concentrated in vacuo