Diisopropylethylamine → HCID 25061105, compound

Participants

Reaction Steps

A reaction mixture of 2-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile (200 mg, 0.70 mmol) and 1-(quinoxalin-6-yl)ethanamine (150 mg, 0.87 mmol) in acetonitrile (2 mL) and N,N-diisopropylethylamine (734 μL, 4.2 mmol) was subjected to microwave irradiation at 185° C. for 3.5 h. The reaction mixture was concentrated and the residue was purified by preparative HPLC (100×20.2 mm, C18 column; 30-60% acetonitrile-water [10 mM Et2NH]) to afford a light brown solid (45 mg).

Provenance & Evidence