tert-Butyldimethylsilyl chloride → HCID 68904863, compound

HRID 657846Notes

Reaction equation

HRID 657846 reaction equation
Cl.[NH2:2][C:3]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([CH3:15])=[C:12]([OH:14])[CH:13]=2)[N:6]=[C:5]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:4]=1.[Si:20](Cl)([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21]>>[C:16]([C:5]1[CH:4]=[C:3]([NH2:2])[N:7]([C:8]2[CH:9]=[CH:10][C:11]([CH3:15])=[C:12]([O:14][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21])[CH:13]=2)[N:6]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 68902171HCID 68902171, compound

Product 1

HCID 68904863HCID 68904863, compoundYield 86%

Procedure

The title compound was prepared from 5-[5-amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-2-methylphenol hydrochloride (WO 03/005999, p81-p82) and tert-butyldimethylsilyl chloride, using the same method as that described for preparation 99, as a solid in 86% yield.

Workup

  1. customthat described for preparation 99, as a solid in 86% yield

Sources & evidence

ORD record
ord-a58b0a3232184ad58b103bb049c4ef07
Source dataset
uspto-grants-2011_12
Patent number
US08076356B2

Reaction notes

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