1-[2-Carbamoylmethyl-3-acetylthiopropanoyl]-L-proline → 1-[2-carbamoylmethyl-3-mercaptopropanoyl]-L-proline

HRID 65787Notes

Reaction equation

HRID 65787 reaction equation
[C:1]([CH2:4][CH:5]([CH2:16][S:17]C(=O)C)[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])(=[O:3])[NH2:2]>O.N>[C:1]([CH2:4][CH:5]([CH2:16][SH:17])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])(=[O:3])[NH2:2]

Participants

4

Reactant 1

HCID 537612811-[2-Carbamoylmethyl-3-acetylthiopropanoyl]-L-proline

Product 1

HCID 867357171-[2-carbamoylmethyl-3-mercaptopropanoyl]-L-proline

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 962WaterSolvent

Procedure

1-[2-Carbamoylmethyl-3-acetylthiopropanoyl]-L-proline (1.2 g.) is dissolved in a mixture of water (20 ml.) and concentrated ammonia (20 ml.). After 15 minutes the reaction mixture is processed as described in "A" above to obtain 1-[2-carbamoylmethyl-3-mercaptopropanoyl]-L-proline.

Sources & evidence

ORD record
ord-5939325670e6426a9f19676460b3afaf
Source dataset
uspto-grants-1978_12
Patent number
US04128721

Reaction notes

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