HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 657895Generated: October 30, 2026
Ethanol → 6,8-Diethoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine
https://huagongshe.com/reaction/657895
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 6-Chloro-8-methanesulfonyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine | HCID 58045800 | — |
| Product | 6,8-Diethoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine | HCID 58045939 | — |
Reaction Steps
6-Chloro-8-methanesulfonyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.126; 60 mg, 0.24 mmol) was dissolved in ethanol (5 ml), sodium ethoxide (500 μl, 21% in ethanol) was added and the mixture was heated to 50° C. for 5 h. The mixture was concentrated and the residue was purified by flash chromatography (dichloromethane:methanol). Yield: 54 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08076336B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-c7a18faa5b3b4511962cdbb3062c4814 |
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| Source note | uspto-grants-2011_12 |
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