Cyanogen Bromide → HCID 58045879, compound

HRID 657913Notes

Reaction equation

FC(F)(F)C(O)=O.[Cl:8][C:9]1[N:14]=[N:13][C:12]([NH:15][NH2:16])=[C:11]([CH:17]2[CH2:19][CH2:18]2)[CH:10]=1.[N:20]#[C:21]Br>>[Cl:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:19][CH2:18]2)[C:12]2[N:13]([C:21]([NH2:20])=[N:16][N:15]=2)[N:14]=1

Participants

Reactant 2

HCID 10476Cyanogen Bromide

HCID 86650806HCID 86650806, compound

Product 1

HCID 58045879HCID 58045879, compound

Conditions

Temperature: 55 °C

Procedure

(6-Chloro-4-cyclopropylpyridazin-3-yl)hydrazine trifluoroacetic acid salt (W3.010; 400 mg) was converted and worked up analogously to W2.009. However, one further equivalent of cyanogen bromide was added and the mixture was additionally stirred at 55° C. for 6 h. 252 mg of the title compound were obtained.

Sources & evidence

ORD record: ord-650022976dab49dd9c6bf5ea184451b0
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08076336B2

Reaction notes

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