Cyanogen Bromide → HCID 58136895, compound

HRID 657914Notes

Reaction equation

HRID 657914 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[N:14]=[N:13][C:12]([NH:15][NH2:16])=[CH:11][C:10]=1[CH:17]1[CH2:19][CH2:18]1.[N:20]#[C:21]Br>>[Cl:8][C:9]1[C:10]([CH:17]2[CH2:19][CH2:18]2)=[CH:11][C:12]2[N:13]([C:21]([NH2:20])=[N:16][N:15]=2)[N:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 86650807HCID 86650807, compound

Product 1

HCID 58136895HCID 58136895, compound

Procedure

(6-Chloro-5-cyclopropylpyridazin-3-yl)hydrazine trifluoroacetic acid salt (W3.012; 400 mg) was converted and worked up analogously to W2.008, except that, instead of 0.5, one further equivalent of cyanogen bromide solution was added. 260 mg of the title compound were obtained in sufficient purity.

Sources & evidence

ORD record
ord-a659cdc789ce451f8229ebcbc67adff7
Source dataset
uspto-grants-2011_12
Patent number
US08076336B2

Reaction notes

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