Cyanogen Bromide → 6-Chloro-8-methanesulfonyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

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Reaction Steps

(6-Chloro-4-methanesulfonylpyridazin-3-yl)hydrazine (W3.126; 200 mg, 0.9 mmol) was dissolved in methanol (5 ml), cyanogen bromide (360 μl, 3 M in DCM) was added and the mixture was stirred at RT for 4 h. The mixture was concentrated and the residue was purified by flash chromatography (dichloromethane:methanol). Yield: 111 mg.

Provenance & Evidence