Hydrazine hydrate (1:1) → HCID 86650809, compound

Participants

Reaction Steps

3,6-Dichloro-4-trifluoromethylpyridazine (W4.004, 150 mg) was dissolved in dioxane (3 ml) and, after hydrazine monohydrate (100 μl) had been added, stirred at RT. After 4 h, the solvent was drawn off and the residue was dissolved in water/ACN and separated by means of preparative HPLC (met. D). The fractions, each of them clean, were combined, freed of the acetonitrile and freeze-dried. 87 mg of (6-chloro-4-trifluoromethylpyridazin-3-yl)hydrazine hydrochloride and 7 mg of (6-chloro-5-trifluoromethylpyridazin-3-yl)hydrazine hydrochloride were obtained.

Provenance & Evidence