HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → (6-Chloro-4-methanesulfonylpyridazin-3-yl)hydrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3,6-Dichloro-4-methanesulfonylpyridazine | HCID 58045789 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (6-Chloro-4-methanesulfonylpyridazin-3-yl)hydrazine | HCID 58045948 | — |
Reaction Steps
3,6-Dichloro-4-methanesulfonylpyridazine(W4.126; 660 mg, 2.9 mmol) was dissolved in 1,4-dioxane (5 ml) and hydrazine hydrate (295 μl, 5.8 mmol) was added. The mixture was stirred at RT for 4 h, then concentrated, and the residue was purified by flash chromatography (dichloromethane:ethyl acetate). Yield: 200 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076336B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-5220c22cc173460384feccb12c1a155e |
| Source note | uspto-grants-2011_12 |