Diethyl Ether → HCID 86650812, compound

HRID 657923Notes

Reaction equation

HRID 657923 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][NH2:9])=[C:4]([CH3:10])[C:3]=1[CH3:11].C1([N:15]=[C:16]=[S:17])CC1.C(O[CH2:21][CH3:22])C.[CH2:23](Cl)Cl>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][N:9]([CH:22]2[CH2:21][CH2:23]2)[C:16]([NH2:15])=[S:17])=[C:4]([CH3:10])[C:3]=1[CH3:11]

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 92463Cyclopropyl isothiocyanateHCID 126480423-Chloro-6-hydrazinyl-4,5-dimethylpyridazine

Product 1

HCID 86650812HCID 86650812, compound

Procedure

(6-Chloro-4,5-dimethylpyridazin-3-yl)hydrazine (W3.006, 540 mg) was dissolved in methylene chloride (50 ml), and cyclopropyl isothiocyanate (290 μl) was added while stirring. The mixture was stirred at RT for 7 h and then left to stand overnight. Thereafter, it was admixed with diethyl ether (50 ml) and stirred for 3 h, and the precipitate formed was filtered off with suction. The precipitate was washed with ether and dried under reduced pressure. 830 mg of the title compound were obtained.

Workup

  1. stirringThe mixture was stirred at RT for 7 h
  2. waitleft
  3. stirringstirred for 3 h
  4. customthe precipitate formed
  5. filtrationwas filtered off with suction
  6. washThe precipitate was washed with ether
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-46b08c050c444cfd8a12685796630f1c
Source dataset
uspto-grants-2011_12
Patent number
US08076336B2

Reaction notes

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