Methyl isothiocyanate → N'-(6-Chloro-4,5-dimethylpyridazin-3-yl)amino-N-methylthiourea

Participants

Role	Name	HCID	Charge
Reactant	Methyl isothiocyanate	HCID 11167	—
Reactant	3-Chloro-6-hydrazinyl-4,5-dimethylpyridazine	HCID 12648042	—
Solvent	Dichloromethane	HCID 6344	—
Product	N'-(6-Chloro-4,5-dimethylpyridazin-3-yl)amino-N-methylthiourea	HCID 58136868	98.8%

Reaction Steps

(6-Chloro-4,5-dimethylpyridazin-3-yl)hydrazine (W3.006; 8.00 g) was dissolved in DCM (400 ml) and admixed with methyl isothiocyanate (3.39 g). Subsequently, the mixture was stirred at RT for 24 h and left to stand over the weekend. The precipitate was filtered off, washed with DCM and dried in a drying cabinet at 45° C. 11.25 g of the title compound were obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08076336B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-fb2d608887ff433d9d973d71dba5562a
Source note	uspto-grants-2011_12