反应详情

1-[3-tert-Butyl-5-(2-methoxyethoxy)phenyl]ethanone (O2.043; 1 g) was dissolved in methanol/THF (25 ml/25 ml), admixed with phenyltrimethylammonium tribromide (882 mg) while stirring and stirred at RT overnight. Then 50 ml of 20% citric acid solution were added and the mixture was stirred for 1 h. Subsequently, DCM (200 ml) was added and the mixture was extracted three times with DCM. Then the combined DCM phases were dried over magnesium sulfate, filtered and concentrated. The residue was purified using silica gel (40 g cartridge, n-heptane/EA gradient of 0-30% in 30 min). 1.31 g of the title compound were obtained.

1. stirringstirred at RT overnight
2. stirringthe mixture was stirred for 1 h
3. extractionthe mixture was extracted three times with DCM
4. dry with materialThen the combined DCM phases were dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified
8. customsilica gel (40 g cartridge, n-heptane/EA gradient of 0-30% in 30 min)