Water → HCID 58045825, compound

Participants

Reaction Steps

1-[3-tert-Butyl-5-(1-hydroxy-1-methylethyl)phenyl]ethanone (O2.100; 500 mg) was initially charged in a mixture of THF and methanol (3.5/3.5 ml) while stirring at RT, and admixed with phenyltrimethylammonium tribromide (800 mg). After stirring at RT for 7 h, the mixture was admixed with water and saturated sodium hydrogencarbonate solution. Then it was extracted three times with EA, and the combined EA phases were dried over sodium sulfate, filtered and concentrated. The residue was purified using silica gel (70 g cartridge, n-heptane/EA gradient). 454 mg of the title compound were obtained. LC-MS rt: 1.23 min [M+H—HOMe]+: 295.1 (met. b)

Provenance & Evidence