1-[3-(Acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline → 1-[2-mercapto-3-(methoxycarbonylmethyl)propanoyl]-L-proline

HRID 65795Notes

Reaction equation

HRID 65795 reaction equation
C([S:9][CH:10]([CH2:21][C:22](OC)=O)[C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])=[O:12])(=O)C1C=CC=CC=1.C(SCC(C[C:43]([O:45][CH3:46])=[O:44])C(N1CCC[C@H]1C(O)=O)=O)(=O)C>>[SH:9][CH:10]([CH2:21][CH2:22][C:43]([O:45][CH3:46])=[O:44])[C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])=[O:12]

Participants

3

Reactant 2

HCID 541123831-[3-(Acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-prolineHCID 54514407HCID 54514407, compound

Product 1

HCID 537277191-[2-mercapto-3-(methoxycarbonylmethyl)propanoyl]-L-proline

Procedure

By substituting 1-[2-(benzoylthio)-3-(methoxycarbonyl)propanoyl]-L-proline for the 1-[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline in the procedure of Example 4, 1-[2-mercapto-3-(methoxycarbonylmethyl)propanoyl]-L-proline is obtained.

Sources & evidence

ORD record
ord-95dce16459f244aea67e1a8484782574
Source dataset
uspto-grants-1978_12
Patent number
US04128721

Reaction notes

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