反应详情

温度

100 °C

N-(3-Acetyl-5-pentafluorosulfanylphenyl)-2,2,2-trifluoroacetamide (O3.075; 9.4 g) was admixed with semiconcentrated sulfuric acid (200 ml), and DCM (15 ml) was added. After stirring at 100° C. for 7 h, the mixture was left to stand overnight. Then the mixture was added to ice-water and extracted with EA. The combined EA phases were washed with saturated sodium hydrogencarbonate solution, dried over magnesium sulfate, filtered and concentrated by rotary evaporation. 6.36 g of the title compound were obtained. LC-MS rt: 1.38 min [M+H]+: 262.0 (met. a)

1. additionwas added
2. waitthe mixture was left
3. waitto stand overnight
4. extractionextracted with EA
5. washThe combined EA phases were washed with saturated sodium hydrogencarbonate solution
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated by rotary evaporation