HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 657998Generated: October 26, 2026
Lithium Hydroxide → 3-tert-Butyl-5-[3-(tetrahydropyran-2-yloxy)propoxy]benzoic acid
https://huagongshe.com/reaction/657998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Methyl 3-tert-butyl-5-[3-(tetrahydropyran-2-yloxy)propoxy]benzoate | HCID 58136886 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-tert-Butyl-5-[3-(tetrahydropyran-2-yloxy)propoxy]benzoic acid | HCID 58136832 | 95.1% |
Reaction Steps
Methyl 3-tert-butyl-5-[3-(tetrahydropyran-2-yloxy)propoxy]benzoate (O5.059; 5.37 g) was dissolved in methanol (80 ml) and THF (160 ml), and lithium hydroxide solution (61.28 ml, 1 M in water) was added. After stirring at 40° C. for 2 h, the mixture was dried, and the residue was taken up with water and freeze-dried. The product obtained was stirred with DCM, filtered and dried. 4.9 g of product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08076336B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-62c46a1187f7407d94a4029922294c9d |
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| Source note | uspto-grants-2011_12 |
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