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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658006Generated: October 31, 2026

2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 58046059, compound

https://huagongshe.com/reaction/658006

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 86621—
ReactantMethyl 3-tert-butyl-5-(hydroxymethyl)benzoateHCID 12144659—
ProductHCID 58046059HCID 5804605941.3%

Reaction Steps

Methyl 3-tert-butyl-5-hydroxymethylbenzoate (3.5 g) was alkylated analogously to O5.059 with 2-(2-bromoethoxy)tetrahydropyran (3.95 g). However, silica gel chromatography (n-heptane/EA 4:1) was carried out for purification. 2.28 g of the title compound were obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076336B2
Source datasetuspto-grants-2011_12
ORD IDord-645109dc67b249cfaa513a2e9870ce85
Source noteuspto-grants-2011_12