Hydrochloric Acid → HCID 66941426, compound

Participants

Reaction Steps

6-(1-Ethylpropoxy)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W1.008; 205 mg) was initially charged in DMF (5 ml) at RT while stirring, and 2-bromo-1-(3-tert-butyl-5-ethoxy-methylphenyl)ethanone (O1.008; 290 mg) was added dropwise predissolved in DMF (5 ml). The reaction mixture was stirred at RT for 14 h. Then the solvent was removed under reduced pressure and the residue was purified using silica gel (40 g cartridge, dichloromethane/ethanol gradient of 0-40% in 60 min). The still contaminated product was subsequently purified by means of preparative HPLC. The clean product fractions were combined, freed of the acetonitrile under reduced pressure and freeze-dried. The residue was dissolved in water and acetonitrile and, after addition of 3 eq. of HCl, freeze-dried. 72 mg of the title compound were obtained.

Provenance & Evidence