反应详情

10% Palladium on carbon (100 mg) was added to a solution of 4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzoic acid benzyl ester (Reference Compound No. 9-1, 970 mg, 2.1 mmol) in methanol (20 mL), and then the reaction mixture was stirred under a hydrogen atmosphere at room temperature for 29 hours. The insoluble was filtered off, and then the solvent was evaporated under reduced pressure. The resulting solid was collected by filtration with ethyl acetate to give 0.78 g of the title reference Compound as a white solid quantitatively.

1. filtrationThe insoluble was filtered off
2. customthe solvent was evaporated under reduced pressure
3. filtrationThe resulting solid was collected by filtration with ethyl acetate
4. customto give 0.78 g of the title reference Compound as a white solid quantitatively