Diisopropylethylamine → HCID 58001077, compound

Participants

Reaction Steps

1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzo triazolium 3-oxide hexafluorophosphate (49 mg, 0.067 mmol) was added to a suspension of N-(2-aminophenyl)-4-[3-(4-carboxyphenyl)-1-(3-dimethylaminopropyl)ureidomethyl]benzamide (Compound No. 4-1, 33 mg, 0.067 mmol), N,N-dimethylaminoethylenediamine (0.30 mL, 2.8 mmol) and N,N-diisopropylethylamine (0.023 mL, 0.13 mmol) in DMF (5.0 mL), and then the mixture was stirred at room temperature for 80 minutes. Saturated aqueous sodium hydrogen carbonate solution (30 mL) was added thereto, the whole was extracted with ethyl acetate (20 mL) twice, and then the organic layer was washed with brine (30 mL) twice. The organic layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform-methanol) to give 21 mg of the title compound as colorless oil. (Yield 57%)

Provenance & Evidence