反应详情

[5-(3-[1,3]Dioxan-2-yl-phenylsulfanyl)-4-fluoro-2-nitro-phenyl]-methanol (2.22 g, 6.08 mmol) was placed in chloroform (250 mL), and MnO2 (6.4 g) was added. The resulting mixture was stirred overnight at room temperature. After 18 h of stirring, the mixture was heated at 40° C. for 1 hour. The resulting mixture was worked up by filtration through Celite®. The filtrate was concentrated to yield an oil, which was purified by silica column chromatography (20% EtOAc/heptane) to yield a solid.

1. stirringAfter 18 h of stirring
2. temperaturethe mixture was heated at 40° C. for 1 hour
3. filtrationThe resulting mixture was worked up by filtration through Celite®
4. concentrationThe filtrate was concentrated
5. customto yield an oil, which
6. customwas purified by silica column chromatography (20% EtOAc/heptane)
7. customto yield a solid