Hydrochloric Acid → 3-[2-Amino-7-fluoro-3-(tetrahydro-pyran-4-ylmethyl)-quinolin-6-ylsulfanyl]-benzaldehyde

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Reaction Steps

In a μwave tube, 6-(3-[1,3]dioxan-2-yl-phenylsulfanyl)-7-fluoro-3-(tetrahydro-pyran-4-ylmethyl)-quinolin-2-ylamine (45 mg, 0.1 mmol) was placed with HCl (conc.) (0.5 mL), H2O (0.5 mL) and diethyl ether (0.2 mL) were reacted via μwave @ 300W, 130° C. for 12 min. The resulting mixture was worked up by removal of solvent to yield a residue, which was purified by silica column chromatography (50% EtOAc/heptanes) to yield a solid.

Provenance & Evidence