2-Bromoethyl isocyanate → HCID 86596235, compound

Participants

Reaction Steps

To a solution of N-(2-mercaptobenzoyl)-β-alaninamide (0.90 g, 4.0 mmol) in DMF (20 ml) was added 2-bromoethyl isocyanate (0.91 g, 6.0 mmol). The reaction mixture was stirred for 6 h. The solvent was evaporated to dryness, and the residue was treated with ethyl ether (20 ml) with vigorous stirring. The precipitate obtained was filtered, washed with water and dried over CaCl2. Yield: 87%. 1H NMR (DMSO-d6): 2.36 (t, 2H, CH2), 3.42 (q, 2H, CH2), 3.54 (s, 4H, 2CH2), 6.88 (brs, 1H, NH2), 7.36-7.66 (m, 5H, Ar—H, NH2), 8.26 (t, 1H, NH), 8.66 (brs, 1H, NH).

Provenance & Evidence