Pyridine → HCID 86596236, compound

Participants

Reaction Steps

A solution of N-[2-(2-bromoethylcarbamylthio)benzoyl]-β-alaninamide (0.37 g, 1.0 mmol) in pyridine (5 ml) was stirred for 8 h under nitrogen. The pyridine was removed in vacuo, and the crude product was purified by column chromatography on silica using chloroform-methanol (7:3 v/v) as eluent. Yield: 82%. 1H NMR (DMSO-d6): 2.38 (t, 2H, CH2), 3.40 (q, 2H, CH2), 3.72 (q, 2H, CH2), 4.72 (t, 2H, CH2), 6.92 (brs, 1H, NH2), 7.36-7.58 (m, 5H, Ar—H, NH2), 8.26 (t, 2H, Py-H), 8.36 (t, 1H, NH), 8.52 (t, 1H, NH), 8.66 (t, 1H, Py-H), 9.12 (d, 2H, Py-H).

Provenance & Evidence